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Diuretic group of carbonic anhydrase inhibitors. It is a weak diuretic effect. It inhibits the enzyme carbonic anhydrase in the proximal convoluted tubules of the nephron increases the excretion of sodium, potassium, bicarbonate, buy testosterone propionate does not affect the excretion of chloride ions; It causes an increase in urine pH. It violates the acid-base balance (metabolic acidosis). Inhibition of carbonic anhydrase of ciliary body reduces the secretion of aqueous humor and reduce intraocular pressure. Inhibition of carbonic anhydrase activity bodybuilding steroid forums in the brain causes the anticonvulsant activity of the drug.

Use of the drug with increased intracranial pressure due to the inhibition of carbonic anhydrase in the plexus of the brain ventricles and decreased production of cerebrospinal fluid.

Duration of action – up to 12 hours.


After oral acetazolamide is well absorbed from the gastrointestinal tract. Upon receiving 500 mg C max of the active agent is 12-27 mg / ml and is achieved in 1-3 hours. Definable acetazolamide plasma concentration is maintained for 24 hours after dosing.

Distribution and metabolism

Mainly distributed in the erythrocytes, kidneys, muscles, tissues and central nervous system of an eyeball. Bound to plasma proteins to a high degree. It penetrates through the placental barrier. Acetazolamide not biotransformed in the body.


Excreted by the kidneys unchanged. About 90% of the dose is excreted in the urine within 24 hours.

Indications – edema syndrome (mild to moderate severity, in combination with alkalosis) – glaucoma (primary and secondary, as well as an acute attack); – epilepsy (as part of combination therapy); – intracranial hypertension; – acute altitude (mountain) disease (the drug reduces the acclimatization period, but its effect on the symptoms expressed slightly).


When edema at the beginning of treatment the drug is prescribed in a dose of 250-375 mg (1-1.5 tab.) 1 times / day in the morning. The maximum diuretic effect is achieved while taking the drug every other day or 2 consecutive days, and then – a one-day break. When using should continue therapy with circulatory failure, including cardiac glycosides, a diet with restriction of salt intake and compensate for the deficiency of potassium.

Adults with open-angle glaucoma drug administered in a single dose of 250 mg (1 tab.) 1-4 times / day. Doses in excess of 1 g does not increase the therapeutic effect. In secondary glaucoma drug administered in a single dose of 250 mg (1 tab.) Every 4 hours. In some patients the therapeutic effect appears after a brief dosing of 250 mg 2 times / day. In acute attacks of glaucoma drug is prescribed 250 mg 4 times / day.

Children with glaucoma attacks Diakarb prescribe a dose rate of 10-15 mg / kg of body weight per day for 3-4 hours.

In epilepsy the adult prescribe on 250-500 mg / day at one time in 3 days, on the 4th day – a break. Children aged from 4 to 12 months 50 mg / day in 1-2 reception; 2-3 years – 50-125 mg / day in 1-2 reception; 4-18 years 125-250 mg 1 time / day in the morning. With simultaneous application of with other anticonvulsant used in the early treatment of 250 mg (1 tab.) 1 times / day, gradually increasing the dose if necessary. Children should not use doses exceeding 750 mg / day.

At a mountain disease recommend the use of the drug at a dose of 500-1000 mg (2-4 tabs.) Per day; in case of rapid ascent – 1000 mg / day. The daily dose is divided into several steps in equal doses. The preparation should be applied for 24-48 h before the ascent, and in case of the onset of symptoms – to continue buy testosterone propionate treatment for the next 48 hours or longer, if necessary.

With missed doses should not increase the dose for the next reception.

Side effect On the part of the central nervous system and peripheral nervous system: convulsions, paresthesia, anorexia, tinnitus, myopia; long-term use – disorientation, disturbance of the sense of touch, drowsiness. From the hematopoietic system: in some cases, long-term use – hemolytic anemia, leukopenia, agranulocytosis. From the water-electrolyte balance and acid-base balance: hypokalemia, metabolic acidosis. Urinary system: . in some cases, long-term use – nephrolithiasis, transient hematuria and glycosuria From the digestive system: anorexia; long-term use – nausea, vomiting, diarrhea.Dermatological reactions: seldom – skin redness, itching. Other: rarely – muscle weakness, allergic reactions.


– acute renal failure; – hepatic impairment; – cirrhosis of the liver; – hypokalemia, – acidosis; – gipokortitsizm; – Addison’s disease; – uremia; – diabetes; – pregnancy; – lactation – Hypersensitivity to the drug.

Pregnancy and lactation

Diakarb contraindicated during pregnancy and lactation.

special instructions

With care prescribe a drug for edema of hepatic and renal origin and a joint reception with acetylsalicylic acid. In appointing the drug for more than 5 consecutive days increases the risk of metabolic acidosis. Precautions should use the drug in elderly patients and / or patients with impaired renal function due increased risk of metabolic acidosis.

Monitoring of laboratory parameters

With long-term use of the drug should be monitored picture peripheral blood, indicators of water and electrolyte balance and acid-base metabolism.

Overdose Symptoms: possibly strengthening described side effects. Treatment: symptomatic therapy.

Drug Interactions When combined with antiepileptic drugs Diakarb amplifies manifestations of osteomalacia. If concomitant use of with other diuretics and theophylline enhanced diuretic effect. With the simultaneous use with acid-forming diuretics, the diuretic effect is reduced. In an application buy testosterone propionate Diakarb increases the risk of manifestation of the toxic effects of salicylates, drugs foxglove , carbamazepine, ephedrine, non-depolarizing muscle relaxants. steroiden kaufen

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