Despres ® forte is used for lowering of mood, depression of mild to moderate severity, accompanied by anxiety, including associated with the climacteric syndrome, hypersensitivity to weather changes.
• Hypersensitivity to testosterone cypionate vs propionate any of the ingredients of the drug;
• photosensitivity (increased sensitivity of the skin to ultraviolet radiation, including in history);
• severe depression severity;
• concomitant use of monoamine oxidase inhibitors (MAOIs), cyclosporine, tacrolimus; . indinavir and other HIV protease inhibitors; irinotecan, imatinib and other cytostatics.; warfarin; other antidepressants;
• Children up to age 12 years;
• pregnancy and breastfeeding;
• a rare hereditary form of galactose intolerance, lactase deficiency or malabsorption of glucose-galactose (as in the composition contains lactose).
Application of pregnancy and during breastfeeding
Use of the drug Despres ® Forte during pregnancy and breast-feeding is contraindicated due to the lack of reliable clinical data supporting the safety of the herb St. John’s wort extract in these periods.
Dosing and Administration
The capsules are taken orally, and washed down with water. Do not open the capsules!
Adults and adolescents over 12 years: 1 capsule 1 time per day, on a regular basis at one and the same time. If necessary, the dose may be increased to two capsules a day, one capsule in the morning and evening.
The greatest effect is achieved with regular drug use for a few weeks.
The therapeutic effect of the drug is 10-14 days after the beginning of reception. If within 4-6 weeks after starting treatment improvement has not come, you should stop taking Deprima ® forte and consult a doctor.
The patient must inform your doctor about what it takes Despres ® forte.
Omitting one reception Deprima ® forte:
• should take the medicine as soon as possible.
• If it is time for your next dose, do not take an extra dose to compensate the missed reception.
• Do not take two doses at the same time.
Disorders of the skin and subcutaneous tissue: skin itching, skin rash, erythema; photosensitivity (more frequently in HIV-infected patients); while taking the drug on skin areas exposed to intense solar radiation, due to photosensitivity may develop skin reactions such as sunburn (mainly in patients with fair skin). Violations of the gastrointestinal tract: nausea, abdominal pain testosterone cypionate vs propionate (incl . epigastric), dryness of the oral mucosa, flatulence, diarrhea or constipation, anorexia, disorders of the nervous system: anxiety, fatigue, headache Disturbances in the blood and lymphatic system: iron deficiency anemia; Other:increased sensitization to animal hair.
So far, cases of overdose have been reported. In applying the drug in doses exceeding the recommended possibly increased severity of dose-related side effects.
Reported the occurrence of seizures and confusion when admission to 4.5 g of dry extract per day for 2 weeks and an additional 15 g of dry extract immediately before hospitalization.
When . substantial overdose may develop phototoxic reactions
Treatment is symptomatic: the drug should be discontinued, take activated charcoal; necessary to avoid exposure to the sun and UV radiation for 1-2 weeks. Activities outdoors should be limited, it is necessary to use the funds and / or clothing that protects the skin from the sun.
Interaction with other drugs
Hypericum perforatum extract activates the microsomal oxidation (cytochrome P450), so while the application reduces the plasma concentrations of the following drugs: digoxin; theophylline; midazolam;tacrolimus; cyclosporine; irinotecan, imatinib and other cytotoxic agents; indirect anticoagulants coumarin (warfarin, phenprocoumon); amitriptyline, nortriptyline; indinavir , and others. HIV protease inhibitors.
The use of a dry extract of Hypericum may reduce and / or reduce the duration of the effect of drugs (eg., fexofenadine, benzodiazepine and derivatives thereof, methadone, simvastatin, finasteride ), metabolism involving isozymes of cytochrome P450 CYP3A4 , CYP2C9, CYP2C19 or P-glycoprotein. Increased enzyme activity is usually restored within 1 week after discontinuation of dry extract of St. John’s wort.
With simultaneous use with selective serotonin reuptake inhibitors (including fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram ), nefazodone, buspirone, or triptans St. John’s wort extract may potentiate the effect of these drugs, including the incidence of side effects (serotonergic effects), such as nausea, vomiting, anxiety, agitation and confusion (serotonin syndrome).
Decreases hypotensive effect of reserpine.
Simultaneous treatment with n eroralnymi contraceptives may weaken their action and lead to intermenstrual bleeding.
Simultaneous treatment with photosensitizing agents may lead to increased phototoxic effects.
It can increase the effects of funds for general anesthesia and narcotic analgesics. Before surgery is necessary to evaluate the potential for interactions with drugs used for local or general anesthesia. If necessary, stop taking St. John’s wort dry extract.
The extract St. John’s wort increases the antidepressant effect of monoamine oxidase inhibitors (MAOIs), this increases the risk of their side effects. The interval between administration of the drug and the MAO inhibitor should be at least 14 days.
If necessary, co-administration of other drugs should be reported to your doctor about your use of St. John’s wort extract.
With simultaneous application of dry extract of St. John’s wort with indirect anticoagulants coumarin (such as phenprocoumon), theophylline and digoxin may decrease their effectiveness. Careful monitoring of patients taking these drugs (eg, control of plasma concentrations), especially at the beginning and at the end of the drug.
The use of a dry extract of St. John’s wort can lead to intermenstrual bleeding in women taking oral contraceptives. It is necessary to use additional contraceptive measures, as the dry St. John’s wort extract can attenuate the effect of oral contraceptives.
During treatment with Despres ® Forte is not recommended to sunbathe or use a solarium.
During treatment with Despres ® Forte should refrain from drinking alcohol.
The product does not contain XE 0.01, which should be considered in the application of patients with diabetes mellitus.
Effects on ability to drive vehicles, machinery
Insufficient data on the effect of the drug on the ability to drive and perform other activities that require high concentration and speed of psychomotor reactions.
International nonproprietary name:
The solution for intramuscular injection.
Active ingredient: Sodium deoxyribonucleate 1.5 g Excipients: sodium chloride 0.9 g Water for injections – 100 ml
Description: transparent colorless liquid.
immunomodulatory agent, a stimulant of hematopoiesis, regenerant, reparant.
The drug activates the processes of cellular and humoral immunity. Immunomodulatory effect is caused by the stimulation of B-lymphocytes, activation of T-helper cells. Derinat activates non-specific resistance of the organism to optimize the inflammatory response and immune response to bacterial, viral and fungal antigens. It stimulates reparative and regenerative processes. Increases the body’s resistance to infections, regulates hematopoiesis (promotes normalization of white blood cells, lymphocytes, granulocytes, phagocytes, platelets). Having expressed lymphotropic, Derinat stimulates drainage and detoxification function of the lymphatic system. Derinat significantly reduces the sensitivity of cells to the damaging effects of chemotherapeutic drugs and radiotherapy. The drug does not have embryotoxic, teratogenic and carcinogenic effects. Pharmacokinetics Absorption and distribution of the drug is rapidly absorbed and distributed in organs and tissues via endolymphatic transportation way. It has a high affinity for bodies of the hematopoietic system, is actively involved in cellular metabolism, embedding into cell structures. In the phase of intensive drug proceeds in the blood is a redistribution between plasma and blood cells in parallel with the metabolism and excretion. After a single injection for all pharmacokinetic curves describing the change in concentration of the drug in the studied organs and tissues, characterized by rapid phase increase and rapid decline phase concentration in the time interval 5-24 hours. The half-life (T V1 / 2) after intramuscular administration is 72.3 hours. Derinat rapidly distributed throughout the body, in the course of daily use of cumulated in organs and tissues: the maximum – in the bone marrow, lymph nodes, spleen, thymus; to a lesser extent – in the liver, brain, stomach, small and large intestines. Maximum concentration in the bone marrow is determined by 5 hours after drug administration. The product overcomes the blood-brain barrier. The maximum concentration of the drug in the brain is achieved after 30 minutes. The metabolism and excretion. Derinat metabolized in the body. Excreted from the body (as metabolites) partly with feces, and to a greater extent in the urine by biexponential dependence.
– radiation damage;
– violation of hematopoiesis;
– mielodeprescia and resistance to cytostatics in cancer patients that developed on the background of cytostatic and / or radiation therapy (stabilization of hematopoiesis, reducing cardio- and myelotoxicity of chemotherapeutic agents);
– stomatitis, induced by cytostatic therapy;
– peptic ulcer and 12 duodenal ulcers, erosive gastroduodenitis;
– ischemic heart disease;
– obliterating leg vessels diseases, chronic ischemia of the lower limbs II – III stage;
– trophic ulcers, nonhealing wounds;
– odontogenic sepsis, purulent-septic complications ;
– rheumatoid arthritis
– burn disease;
– preoperative and postoperative periods (in surgery);
– endometritis, salpinogooforit, endometriosis, fibroids;
– chlamydia, ureaplasmosis, mycoplasmosis;
– prostatitis, benign prostatic hyperplasia;
– chronic obstructive pulmonary disease;
– pulmonary tuberculosis, inflammatory airway disease.
Use during pregnancy and lactation
is necessary to consult a doctor. The appointment of the drug during pregnancy should assess the expected benefit to the mother and the potential risk to the fetus. During lactation apply strictly on prescription.
Dosage and administration Adults: intramuscular injection for 1-2 minutes with 5 ml of 1.5% (75 mg) of the solution, with an interval of 24-72 hours. In ischemic heart disease – 10 injections with an interval of 48-72 hours. If a peptic ulcer gastric and 12 duodenal ulcer – 5 injections with an interval of 48 hours. At oncological diseases – 3-10 injections at an interval of 24-72 hours. In gynecology (endometritis, chlamydia, ureaplasmosis, mycoplasmosis, salpinogooforit, fibroids, endometriosis) – 10 injections with an interval of 24-48 hours. In andrology (prostatitis, benign prostatic hyperplasia) – 10 injections with an interval of 24-48 hours. If pulmonary tuberculosis – 10-15 injections with an interval of 24-48 hours. In case of acute inflammatory diseases – 3-5 injections at intervals of 24-72 hours. In chronic inflammatory diseases – 5 injections with an interval of 24 hours, then – 5 injections, at intervals of 72 hours. When using a 1.5% solution in 2 ml intramuscular injections done daily, making conversion, to achieve course dose 375-750 mg.
Children drug designate intramuscularly in the same way as adults. Children under 2 years of drug administered in a single dose of 7.5 mg (0.5 mL). In children aged from 2 to 10 years, a single dose is determined by the rate of 0.5 ml per year of life. From the age of 10 single dose – 5 ml of 1.5% solution, course dose – up to 5 injections (15 mg / ml) of the drug.
In patients with diabetes is marked hypoglycemic action that should be taken into account by testosterone cypionate vs propionate controlling blood sugar levels.
negative phenomena have been identified from an overdose.
Interaction with other medicinal products
The use of Derinat in combination therapy can improve efficiency and reduce the duration of treatment, with a substantial reduction doses of antibiotics and antiviral agents with increasing periods of remission.
Derinat increases the effectiveness of anticancer antibiotics anthracyclines, cytostatic drugs.
The drug potentiates the therapeutic effect of basic therapy in peptic ulcer disease stomach and duodenum 12. Derinat reduce iatrogenic basic drugs for the treatment of rheumatoid arthritis with the achievement of 50% and 70% improvement on a number of complex indicators of disease. Active
Surgical sepsis introduction Derinat in the complex therapy causes a decrease intoxication level, the activation of immune system, normalization of blood, improves the functioning of the bodies responsible for the processes of the internal environment of the body detoxification (lymph nodes, spleen, etc.).
The drug can be administered subcutaneously.
The solution for intramuscular injection of 15 mg / ml. In 5 ml bottles of imported glass with injection infusion plugs in trays, blister packs in a cardboard bundle number 5 or 2 ml vials of imported glass with injection infusion plugs in trays, blister packs in a cardboard bundle number 10. Running low dose t3 clen cycle trying to lose bodyfat isn’t a real hot idea imo.