Despres ® is used for lowering of mood, depression of mild to moderate severity, accompanied by anxiety, including associated with the climacteric syndrome, hypersensitivity testosterone propionate cream to weather changes.
• Increased individual sensitivity to the ingredients of the drug;
• photosensitivity (increased sensitivity of the skin to ultraviolet radiation, including in history);
• severe depression severity;
• concomitant use of monoamine oxidase inhibitors (MAOIs), cyclosporine, tacrolimus; . indinavir and other HIV protease inhibitors; irinotecan, imatinib and other cytostatics.; warfarin; other antidspressantami;
• Children up to age 12 years;
• pregnancy and breastfeeding;
• a rare hereditary form of galactose intolerance, lactase deficiency or malabsorption of glucose-galactose (as in the composition contains lactose).
Application of pregnancy and during breastfeeding
Use of the drug Despres ® during pregnancy and breast-feeding is contraindicated due to the lack of reliable clinical data supporting the safety of the herb St. John’s wort extract in these periods.
Dosing and Administration
The tablets are taken orally and washed down with water. Adults and adolescents over 12 years old . One tablet 3 times daily The therapeutic effect of the drug Despres ® . Appears 10-14 days after the beginning of reception If within 4-6 weeks after the start of treatment did not improve come, you should stop taking Despres drug ® and consult a doctor. The patient must inform your doctor about what it takes Despres ® . When skipping a reception Despres drug ® • should take the medicine as soon as possible. • if it is time for your next dose, do not take an extra dose to compensate the missed reception. • Do not take two doses at the same time.
Disorders of the skin and subcutaneous tissue: skin itching, skin rash, erythema; photosensitivity (more frequently in HIV-infected patients); while taking the drug on skin areas exposed to intense solar radiation, due to photosensitivity may develop skin reactions such as sunburn (mainly in patients with fair skin). Violations testosterone propionate cream of the gastrointestinal tract: nausea, abdominal pain (incl . epigastric), dryness of the oral mucosa, flatulence, diarrhea or constipation, anorexia, disorders of the nervous system: anxiety, fatigue, headache Disturbances in the blood and lymphatic system: iron deficiency anemia; Other:increased sensitization to animal hair.
So far, cases of overdose have been reported. In applying the drug in doses exceeding the recommended possibly increased severity of dose-related side effects.
Reported the occurrence of seizures and confusion when admission to 4.5 g of dry extract per day for 2 weeks and an additional 15 g of dry extract immediately before hospitalization.
When . substantial overdose may develop phototoxic reactions
Treatment is symptomatic: the drug should be discontinued, take activated charcoal; necessary to avoid exposure to the sun and UV radiation for 1-2 weeks. Activities outdoors should be limited, it is necessary to use the funds and / or clothing that protects the skin from the sun.
Interaction with other drugs
Hypericum perforatum extract activates the microsomal oxidation (cytochrome P450), so while the application reduces the plasma concentrations of the following drugs: digoxin; theophylline; midazolam;tacrolimus; cyclosporine; irinotecan, imatinib and other cytotoxic agents; indirect anticoagulants coumarin (warfarin, phenprocoumon); amitriptyline, nortriptili; indinavir , and others. HIV protease inhibitors.
The use of a dry extract of Hypericum may reduce and / or reduce the duration of the effect of drugs (eg., fexofenadine, benzodiazepine and derivatives thereof, methadone, simvastatin, finasteride ), metabolism involving isozymes of cytochrome P450 CYP3A4 , CYP2C9, CYP2C19 or P-glycoprotein. Increased enzyme activity is usually restored within 1 week after discontinuation of dry extract of St. John’s wort.
While the use of selective serotonin reuptake inhibitors (including fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram), nefazodone, buspirone, or triptans St. John’s wort extract may potentiate the effect of these drugs, including the incidence of side effects (serotonergic effects), such as nausea, vomiting, anxiety, agitation and confusion (serotonin syndrome).
Decreases hypotensive effect of reserpine.
Simultaneous treatment with oral contraceptives and may weaken their action and lead to intermenstrual bleeding.
Simultaneous treatment with photosensitizing agents may lead to increased phototoxic effects.
It can increase the effects of funds for general anesthesia and narcotic analgesics. Before surgery is necessary to evaluate the potential for interactions with drugs used for local or general anesthesia. If necessary, stop taking St. John’s wort dry extract.
The extract St. John’s wort increases the antidepressant effect of monoamine oxidase inhibitors (MAOIs), this increases the risk of their side effects. The interval between administration of the drug and the MAO inhibitor should be at least 14 days.
If necessary, co-administration of other drugs should be reported to your doctor about your use of St. John’s wort extract.
With simultaneous application of dry extract of St. John’s wort with indirect anticoagulants coumarin (such as phenprocoumon), theophylline and digoxin may decrease their effectiveness. Careful monitoring of patients taking these drugs (eg, control of plasma concentrations), especially at the beginning and at the end of the drug.
The use of a dry extract of St. John’s wort can lead to intermenstrual bleeding in women taking oral contraceptives. It is necessary to use additional contraceptive measures, as dry extract of St. John’s wort may weaken the effect of oral contraceptives.
During treatment with testosterone propionate cream Despres ® is recommended not to sunbathe or use a solarium.
During treatment with Despres ® should refrain from drinking alcoholic beverages. The product contains 0.02 XE, which should be considered in the application of patients with diabetes mellitus.
Effects on ability to drive vehicles, machinery
Insufficient data on the impact of preparty on ability to drive and perform other activities that require high concentration and speed of psychomotor reactions.