• burn treatment and prevention of infections, including up to autodermoplasty;
• the treatment and prevention of infection of trophic ulcers, wounds.
• Hypersensitivity to sulfadiazine, other sulfanilamides or any component of the drug;
• premature newborns and children during the first 2 months after birth;
• Deficiency of glucose-6-phosphate dehydrogenase (risk of hemolysis);
• renal and / or hepatic impairment.
Application of pregnancy and during breastfeeding
Data on the testosterone propionate dosage use of silver sulfadiazine during pregnancy and lactation is limited. Application of medication Dermazin ® during pregnancy and lactation is contraindicated.
If systemic administration of sulfonamides in newborns can occur hyperbilirubinemia and kernicterus as sulfonamides displace bilirubin from plasma albumin.
Sulfonamides are allocated in small amounts in breast milk. If necessary, use of the drug Dermazin ® during lactation should decide the issue of termination of breastfeeding.
Dosing and Administration
After debridement Dermazin ® cream is applied a layer thickness of 2-4 mm on the damaged area once or twice a day until complete healing of the wound surface.
Before each re-applying the cream is necessary to remove the previous layer water preparation or antiseptic drugs.
Dermazin ® can Apply to use with sterile dressings or without dressings should be changed daily. When changing dressings is not observed ill effects.
Dermazinom Treatment ® is continued until complete healing of the wound surface.
A method of applying the cream is the same for the treatment of burns and trophic ulcers.
According to the World Health Organization (WHO), undesirable effects are classified according to their rate of development as follows: very common (≥1 / 10), commonly (≥1 / 100, <1/10), uncommon (≥1 / 1000, < 1/100), rare (≥1 / 10,000, <1/1000) and very rare (<1/10000); frequency not known (frequency of events can not be determined on the basis of available data). On the side of the blood and lymphatic system Uncommon: leukopenia (in 3-5% of patients), which is characterized mainly decrease in the number of neutrophils; Maximum reduction of leukocytes observed on 2-4 th day after the start of treatment, then their normal level within 2-3 days, and the continuation of treatment Dermazin ® has no effect on leukocyte recovery process. were post-marketing According observations identified the following adverse reactions: Hematopoietic and lymphatic organs frequency is unknown: increasing osmolality of blood plasma. immune system frequency is not known: hypersensitivity reactions. skin and subcutaneous structures are very rare: Stevens-Johnson syndrome, toxic epidermal necrolysis, frequency unknown : allergic skin reactions such as rash, pruritus, contact dermatitis, gray staining of the skin by the action of sunlight. General disorders and the site of application frequency is unknown: . burning sensation or pain Systemic absorption of silver sulfadiazine in very rare cases, can cause adverse reactions similar to those during systemic therapy sulfonamides (skin rash, Stevens-Johnson syndrome, exfoliative dermatitis, erythema multiforme, interstitial nephritis, eosinophilia, eczema, disruption of water and electrolyte balance, fever, hypoglycemia, purpura, photodermatosis, erythema nodosum, headache , joint pain, folic acid deficiency).
With prolonged use at high body surface sulfanilamide concentration in serum may approach the level achieved with the application of the system, which increases the risk of adverse reactions specific to sulfa drugs; in these cases it is recommended to determine the serum concentration of silver sulfadiazine. Treatment testosterone propionate dosage is symptomatic, appointed by drinking plenty of fluids (recommended to maintain a daily urine output at the level of 1200 – 1500 ml or more). Argyria due to increased systemic absorption of silver does not develop.
Interaction with other drugs
Silver sulfadiazine may inactivate the enzyme preparations for cleaning at their simultaneous application of the wound.
It is noted that the simultaneous application of cimetidine may increase the incidence of leukopenia.
With extensive burns, when the plasma concentration of silver sulfadiazine can reach therapeutic values, be aware that the effect of other systemic drugs can vary . In such cases, the need to control serum concentrations of the drug, kidney function, and urine in order to exclude the possible presence of silver sulfadiazine.
Silver Sulfadiazine can increase the effects of anticoagulants, oral hypoglycemic drugs sulfonylureas, methotrexate sodium thiopental.
In an application with probenecid, indomethacin , phenylbutazone, salicylates, sulfinpyrazone may increase the action of sulfanilamide.
in an application with atsidifitsiruyuschimi urine means (eg, calcium chloride, ascorbic acid at high doses) may develop crystalluria.
It should be used with caution in drug Dermazin ® in patients with renal failure and damage to the liver parenchyma.
Patients with deficiency of glucose-6-phosphate dehydrogenase should be under a doctor’s supervision.
With prolonged use cream Dermazin ® on the large surface of the skin should monitor blood count because of the possible development of leukopenia.
in applying the drug Dermazin ® can develop Stevens-Johnson syndrome, toxic epidermal necrolysis, especially in the first weeks of the drug.
If you have any symptoms of these diseases (progressive skin rash, accompanied by blisters or mucosal lesions), drug treatment should be discontinued. The testosterone propionate dosage best results in the treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis are marked in the early diagnosis and immediate discontinuation of any suspect drug.
Patients in whom the treatment of sulfadiazine developed Stevens-Johnson syndrome and toxic epidermal necrolysis, it is not recommended to re-use the drug containing sulfadiazine.
Parts of the body treated with the drug Dermazin ® , should be protected from direct sunlight.
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